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I did it this morning and not since. When I had oral surgery they told me to do exactly that every 6 hours - I only did it every 12 hours. Advil and Tylenol are fine together (although I don't take Tylenol more than several times a year - bad for your liver). Advil and Aleve are both NSAIDs - not something I do together often but with my pain level at a point that I was even being mean to my cat - I told him to shut up. He was meowing for me to turn on the sink - he only drinks running water - he even has a fountain downstairs. I was a hot mess. Ended up being a good day. Got a lot of work done sitting in my comfy chair that looks like crap - needs to be reupholstered - but I cover it with a quilt. One of my favorite things in life. (Attachment Link)